GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1.

Caleb A Padgett,Róbert K Bátori,Andrew C Speese,Cody L Rosewater,Weston B Bush,Cassandra C Derella,Stephen B Haigh,Hunter G Sellers,Zachary L Corley,Madison A West,James D Mintz,Brittany B Ange,Ryan A Harris,Michael W Brands,David J R Fulton,David W Stepp

Arteriosclerosis, thrombosis, and vascular biology（2023）

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Abstract

Deletion of GAL3 normalizes microvascular endothelial function in obese mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.

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