Bayesian modeling disentangles language versus executive control disruption in stroke

Stroke is the leading cause of long-term disability worldwide. Incurred brain damage disrupts cognition, often with persisting deficits in language and executive capacities. Despite their clinical relevance, the commonalities, and differences of language versus executive control impairments remain under-specified. We tailored a Bayesian hierarchical modeling solution in a largest-of-its-kind cohort (1080 stroke patients) to deconvolve language and executive control in the brain substrates of stroke insults. Four cognitive factors distinguished left- and right-hemispheric contributions to ischemic tissue lesion. One factor delineated language and general cognitive performance and was mainly associated with damage to left-hemispheric brain regions in the frontal and temporal cortex. A factor for executive control summarized control and visual-constructional abilities. This factor was strongly related to right-hemispheric brain damage of posterior regions in the occipital cortex. The interplay of language and executive control was reflected in two factors: executive speech functions and verbal memory. Impairments on both were mainly linked to left-hemispheric lesions. These findings shed light onto the causal implications of hemispheric specialization for cognition; and make steps towards subgroup-specific treatment protocols after stroke. ### Competing Interest Statement The authors have declared no competing interest. * BNT : Boston Naming Test DSCT : Digit Symbol Coding Task IQCODE : Informant Questionnaire on Cognitive Decline in the Elderly MDN : multiple-demand network MIMO : multiple-input multiple-output MMSE : Mini Mental State Exam MISO : multiple-input single-output NMF : non-negative matrix factorization RCF : Rey Complex Figure SVL : Soul Verbal Learning TMT : Trail Making Test