CytoPb: Segmentation-free and threshold-free analysis of highly multiplexed images of biological tissue
bioRxiv (Cold Spring Harbor Laboratory)(2023)
Abstract
We present a novel method and code, CytoPb, for the analysis of multiplexed images that is segmentation-free and threshold-free and produces results that correlate well with existing methods but is faster to run, needs minimal training and removes subjectivity associated with the validation of single-cell segmentation and thresholding. In three data sets cell abundance measures correlate with previous methods (Pearson’s coef. >0.75). Neighbourhood analysis and cell-cell proximity are possible.
### Competing Interest Statement
The authors have declared no competing interest.
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Key words
multiplexed images,biological tissue,segmentation-free,threshold-free
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