Olaparib-induced pseudoporphyria in a patient with ovarian cancer

Pseudoporphyria is a rare and poorly understood bullous photodermatosis associated with certain phototoxic medications, UV radiation, hemodialysis, and indoor tanning bed use. Although pseudoporphyria closely resembles porphyria cutanea tarda (PCT) from a clinical and histologic standpoint, there are characteristically no laboratory abnormalities.1 Patients with pseudoporphyria typically present with skin fragility, vesicles, bullae, milia, and/or scarring in photoexposed areas. Although involvement of the dorsal aspect of the hands is most common, the characteristic lesions of pseudoporphyria can also be found on the extensor legs, fingers, upper portion of the chest, and face.