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SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis.

Xiao-Wei Wang,Ying-Hao Jiang,Wei Ye,Chun-Fa Shao,Jian-Jin Xie,Xia Li

Cancer biology & therapy（2023）

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Abstract
In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.
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colorectal cancer, chemoresistance, SIRT1, p53, MiR-101, KPNA3, metastasis, epithelial-mesenchymal transformation, >
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