Clinical and Diagnostic Findings of Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy in the COVID-19 Era.

Optical coherence tomography (OCT) findings in AMN patients were hyper-reflectivity (HR) of the outer plexiform layer (OPL), of the outer nuclear layer (ONL), and ellipsoid or interdigitate zones (EZ and IZ, respectively) disruption. In most cases, the presence of HR and EZ/IZ abnormalities resulted combined. When performed, OCT angiography (OCTA) identified attenuation of signal of the deep capillary plexus (DCP). The most common OCT finding in PAMM was an alteration of the inner nuclear layer (INL), associated with other areas of HR, while no signs of EZ/IZ disruption were detected. When performed, OCT-A showed the attenuation of signal of both the DCP, and the superficial capillary plexus (SCP) Discussione/Conclusion: In this review we reported a case series of AMN and PAMM in patients with a previous or concomitant infection from SARS-CoV-2. The microvascular changes in these cases are highlighted by the OCTA scans. Even if we are far from the determination of a direct link between COVID-19 and these retinal disorders, we could hypothesize that the vascular alterations associated with Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection could be a possible risk factor for both AMN and PAMM.