新型阴道用半固体制剂的质量表征与体外特性评价概述
Chinese Journal of Pharmaceuticals（2023）
Abstract
阴道因具有血流丰富、给药面积大和无肝脏首过效应等优势,有利于药物发挥疗效.在阴道药物递送系统中,半固体制剂具有一定的流动性,在阴道中的铺展面积比固体制剂大,增加了阴道黏膜对药物的吸收效率.阴道用温敏凝胶可响应温度的变化,从液体转为半固体,因而兼具易于铺展和抵抗阴道液冲刷的效果.该研究通过检索文献,综述了阴道用半固体制剂的质量表征和体外评价方法,以期为半固体制剂的进一步开发提供参考.
MoreKey words
vaginal drug delivery system,semi-solid preparation,temperature-responsive gel,quality characterization,in vitro evaluation
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