2-[(2-乙基-5-氟苯并呋喃-3-基)甲基]-4-甲基-5-噻唑甲酸合成路线的改进
Chemistry & Bioengineering（2023）
Abstract
在课题组前期2-[(2-乙基-5-氟苯并呋喃-3-基)甲基]-4-甲基-5-噻唑甲酸合成路线的基础上进行改进,以5-氟水杨醛为起始原料,经环合、还原、亲电取代、硫代、环合、水解反应得到 目标化合物,化合物结构经1HNMR、13CNMR和HRMS确证.与原合成路线相比,该路线减少了合成步骤,目标化合物总收率由0.3％提高到5.0％.
MoreKey words
xanthine oxidase,2-((2-ethyl-5-fluorobenzofuran-3-yl)methyl)-4-methylthiazole-5-carboxylic acid,synthesis,improvement
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