High CD4+:CD8+ ratios with herpes zoster infections in patients with multiple sclerosis on dimethyl fumarate.

Alexandra Balshi,Emma Saart,Sarbesh Pandeya,John Dempsey,Ursela Baber,Jacob A Sloane

Multiple sclerosis (Houndmills, Basingstoke, England)（2023）

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摘要

Patients with MS who develop HZ while on DMF have high CD4+:CD8+ ratios, suggesting an imbalance of CD4+ and CD8+ cells that may put a patient at risk for developing HZ while on DMF. This result emphasizes the need for lymphocyte subset monitoring (including CD4+:CD8+ ratios) on DMF, as well as vaccination prior to DMF initiation.

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关键词

Dimethyl fumarate, multiple sclerosis, disease-modifying therapies, immunology

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