Cytokine Gene Expression Profiles during HIV and Helminth Coinfection in Underprivileged Peri-Urban South African Adults.

Miranda N Mpaka-Mbatha,Pragalathan Naidoo,Khethiwe N Bhengu,Md Mazharul Islam,Ravesh Singh, Nomzamo Nembe-Mafa,Zilungile L Mkhize-Kwitshana

Diagnostics (Basel, Switzerland)（2023）

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摘要

The coinfected group had higher proinflammatory Th1- and Th17-related cytokine gene expression profiles compared to the uninfected controls. The findings suggest that pro-inflammatory responses are elevated during coinfection, which supports the hypothesis that helminths have a deleterious effect on HIV immune responses.

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hiv,helminth coinfection,african adults,peri-urban

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