Selecting an appropriate all-oral short-course regimen for patients with multidrug-resistant or pre-extensive drug-resistant tuberculosis in China: A multicenter prospective cohort study

Liang Fu,Xilin Zhang,Juan Xiong,Feng Sun,Taoping Weng,Yang Li,Peize Zhang,Hui Li,Qianting Yang,Yi Cai,Hancheng Liang,Qiuqi Chen,Zhaoqing Wang, Lei Liu,Xinchun Chen,Wenhong Zhang,Guofang Deng

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2023）

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Abstract

•Three new multidrug-resistant tuberculosis (MDR-TB)/ pre-extensive drug-resistant tuberculosis (pre-XDR-TB) regimens, five drugs for 9 months.•The first cohort of short-course regimens for MDR-TB in China.•Of 99 assessable participants, 92.9% had a favorable outcome.•Culture conversion was 82.5% at month 2 and 97.9% at month 6.•Majority of adverse effects were manageable and reversible.

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Key words

Multidrug-resistant tuberculosis,Pre-extensive drug-resistant tuberculosis,Treatment,Short-course,Safety

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