Application of the ViroKey® SQ FLEX assay for detection of cytomegalovirus antiviral resistance

Jocelyn Hume,Kym Lowry,David M. Whiley,Adam D. Irwin,Cheryl Bletchly,Emma L. Sweeney

Journal of Clinical Virology（2023）

Cited 0|Views7

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Abstract

•First account of ViroKeyࣨ® SQ FLEX assay for CMV antiviral resistance genotyping.•Common ganciclovir resistant mutations in Queensland consistent with those globally.•Need for global CMV antiviral resistant mutation database.•Majority of CMV samples from children are below 1000 IU/mL.•Greater sensitivity required from NGS protocols for CMV antiviral resistance genotyping.

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Key words

Cytomegalovirus,Antiviral resistance,Next generation sequencing,Genotyping,Mutations

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