Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease.

Yiming Ding,Xulei Dai,Miaoye Bao,Yuanming Xing,Junhui Liu,Sihai Zhao,Enqi Liu,Zuyi Yuan,Liang Bai

Animal models and experimental medicine（2023）

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摘要

Our findings show that HFD-fed mice and ob/ob mice can mimic human NAFL partly in pathophysiological process. The comparative analysis of liver transcriptome profile in mouse models and human NAFL presented here provides insights into the molecular characteristics across these NAFL models.

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关键词

animal model, high-fat diet, nonalcoholic fatty liver disease, ob, ob mice, transcriptomics

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