The Role of Diversion During Ileal Pouch Anal Anastomosis (IPAA) Creation in Pediatric Ulcerative Colitis
Journal of pediatric surgery(2023)
摘要
Introduction: In pediatric ulcerative colitis (UC), surgery is often postponed until disease is life-threat-ening or refractory to immune suppression. In these settings, diverting ileostomy (DI) is theorized to have a protective effect on the new anastomosis. However, analyses have been performed only in single -institution series and the true impact of performing DI at the time of IPAA on postoperative outcomes is unclear. Methods: We performed a retrospective cohort study using claims data from the International Business Machines (IBM) MarketScan (R) database. Patients were sorted to the DI group if they carried a CPT code for ostomy closure within 6 months of index procedure. We examined demographics, preoperative risk factors, and performed regression analysis to compare 30-day postoperative outcomes between groups. Results: We identified 317 patients <= 18yo that underwent IPAA procedure and met inclusion criteria from 2000 to 2019. Of these, 238 patients were assigned to the IPAA + DI cohort and 79 patients were assigned to the IPAA cohort. Adverse outcomes were comparable between cohorts. Surgical site infection (SSI) rates between IPAA and IPAA + DI were 10.1 vs. 11.3% (p = 0.67). Rates of intra-abdominal drainage procedures were 3.8 vs. 2.1% (p = 0.39). The rates of 30-day readmissions were 16.5 vs. 19.3% (p = 0.39). Creation of a DI was not associated with higher odds of 30-day readmission (OR = 1.4, p = 0.31). Conclusion: Creating a DI necessitates an additional surgery for closure and is not associated with decreased adverse outcomes. There is still a role for multicenter studies to define which patient pop-ulations may benefit from diversion.Level of Evidence: Retrospective comparative study.Type of Study: Level III. (c) 2023 Elsevier Inc. All rights reserved.
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关键词
Ulcerative colitis,Diverting ileostomy,Outcomes,Ileal-pouch anal anastomosis
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