Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade-induced pyroptosis.

Ting Yao,Le Xie,Yao Xie, Jinlin Jiang, Qian Deng,Jie Wang,Lu Liu,Dahua Wu

Neuropeptides（2023）

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摘要

Zishen Huoxue recipe can upregulate miR-124-3p expression to repress the inflammatory cascade-evoked pyroptosis, thereby protecting against neuronal injury in the NVU of VD rats.

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关键词

Zishen Huoxue recipe,Vascular dementia,Neurovascular unit,0,NLRP3 inflammasome,miR-124-3p,Inflammatory cascade response,Co-culture system

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