Ring Opening of Substituted 3-[2-(4-Nitrobenzoyl)hydrazinylidene]furan-2(3 H )-ones with Primary Alcohols. Analgesic Activity and Acute Toxicity of the Products
Russian Journal of Organic Chemistry（2023）
Abstract
Ring opening of 5-substituted 3-[2-(4-nitrobenzoyl)hydrazinylidene]furan-2(3 H )-ones by the action of alcohols afforded the corresponding 4-substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobutanoates. The synthesized compounds were evaluated for analgesic activity and acute toxicity. They showed a pronounced analgesic effect in combination with low toxicity and can be regarded as almost nontoxic compounds.
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Key words
2,4-dioxobutanoic acids, 3-imino(hydrazinylidene)furan-2(3H)-ones, analgesic activity, toxicity, alcohols
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