One-pot chemical synthesis of small ubiquitin-like modifier protein–peptide conjugates using bis (2-sulfanylethyl)amido peptide latent thioester surrogates

Protein SUMOylation, which has a crucial role in the regulation of important cellular processes, is difficult to replicate using living systems in the lab. Boll et al . describe here the chemical synthesis of functional SUMO-peptide conjugates.