Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

Laure Crabbé,Aubin Thomas,Véronique Pantesco,John De Vos,Philippe Pasero,Armelle Lengronne

Nature Structural & Molecular Biology（2010）

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摘要

genome-wide analysis of replication profiles in different budding yeast mutants reveals that the alternative clamp loader component Ctf18 has a key role in the DNA replication checkpoint, acting together with Mrc1 to promote Rad53 phosphorylation.

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