A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation

Shima Nakanishi,Brian W Sanderson,Kym M Delventhal,William D Bradford,Karen Staehling-Hampton,Ali Shilatifard

Nature Structural & Molecular Biology（2008）

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Abstract

comprehensive library encompassing alanine scanning mutations across yeast histones is presented as a Resource that will facilitate screening of chromatin processes. The utility of the library is indicated by screening in cis and in trans for residues that affect histone H3K4 trimethylation, a modification that is associated with actively transcribed genes and known to be mediated by the Set1-COMPASS complex.

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