Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

During Wallerian degeneration of Drosophila axons, Draper and Crk/Mbc/dCed-12 signaling non-redundantly promote clearance of axonal debris. Draper signaling is required early to activate glial responses to axonal injury, whereas Crk/Mbc/dCed-12 are dispensable for glial activation, but are essential at the phagocytic step for internalization and degradation of axonal debris.