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The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR

Trang T T Nguyen,Kathrin Kläsener, Christa Zürn,Patricia A Castillo,Ingrid Brust-Mascher,Denise M Imai,Charles L Bevins,Colin Reardon,Michael Reth,Nicole Baumgarth

Nature Immunology（2017）

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Abstract
FcμR serves as a receptor for soluble IgM. Baumgarth and colleagues show that intracellular FcμR constrains the surface expression of IgM. Lack of FcμR alters B cell populations and enhances autoantibody production. FcμR thereby serves as a critical regulator of B cell homeostasis.
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