USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
Nature Immunology(2016)
Abstract
Cerebral malaria infection can provoke fatal neuroinflammation. Gros and colleagues identify an ubiquitin-modification axis that exacerbates neuroinflammation and that involves TRIM25 and USP15, which jointly promote type I interferon production.
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