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USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

Sabrina Torre,Maria J Polyak,David Langlais,Nassima Fodil,James M Kennedy,Irena Radovanovic,Joanne Berghout,Gabriel A Leiva-Torres,Connie M Krawczyk,Subburaj Ilangumaran,Karen Mossman,Chen Liang,Klaus-Peter Knobeloch,Luke M Healy,Jack Antel,Nathalie Arbour,Alexandre Prat,Jacek Majewski,Mark Lathrop,Silvia M Vidal,Philippe Gros

Nature Immunology（2016）

Cited 57|Views0
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Abstract
Cerebral malaria infection can provoke fatal neuroinflammation. Gros and colleagues identify an ubiquitin-modification axis that exacerbates neuroinflammation and that involves TRIM25 and USP15, which jointly promote type I interferon production.
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