Defective survival of naive CD8 + T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels
Nature Immunology(2009)
摘要
T cell activation triggers large calcium fluxes. Flavell and colleagues show tonic calcium signaling via Ca v 1.4-β3 channels are needed for the survival and homeostasis of naive CD8 + T cells.
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