Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

Chia-Wei Hu,Matthew Worth,Dacheng Fan,Baobin Li,Hao Li,Lei Lu,Xiaofang Zhong,Ziqing Lin,Liming Wei,Ying Ge,Lingjun Li,Jiaoyang Jiang

Nature Chemical Biology（2017）

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摘要

N -Acetylglucosamine derivatives equipped with electrophilic groups and handles for subsequent chemical tagging are useful probes of substrate recognition by O-GlcNAc transferases and enable the capture of transient protein substrates of these enzymes.

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