The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Mark M Pomerantz,Nasim Ahmadiyeh, Li Jia,Paula Herman,Michael P Verzi,Harshavardhan Doddapaneni,Christine A Beckwith,Jennifer A Chan,Adam Hills,Matt Davis,Keluo Yao,Sarah M Kehoe,Heinz-Josef Lenz, Christopher A Haiman,Chunli Yan,Brian E Henderson,Baruch Frenkel,Jordi Barretina,Adam Bass, Josep Tabernero, José Baselga,Meredith M Regan,J Robert Manak,Ramesh Shivdasani,Gerhard A Coetzee,Matthew L Freedman

Nature Genetics（2009）

Cited 547|Views0

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Abstract

Matthew Freedman and colleagues show that a region on 8q24 associated with colorectal cancer risk functions as an enhancer and undergoes long-range interactions with MYC . They further show that alleles at the risk-associated SNP bind differentially to TCF7L2, a transcription factor in the Wnt pathway.

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