Abnormal [ 18 F]fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease
Annals of Nuclear Medicine(2021)
Abstract
Objectives Tubarial glands (TGs) are recently refocused gland tissues localized near the tori tubarius in the nasopharynx and their clinical relevance is not clear yet. IgG4-related disease (IgG4-RD) is a progressive fibrosing condition and salivary glands are well-affected lesions. The aim of the present study is to examine [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) accumulation to the tori tubarius in IgG4-related disease (IgG4-RD). Methods 48 patients with IgG4-RD who underwent positron emission tomography (PET) scanning with [ 18 F]FDG were included and semi-quantitative analysis of [ 18 F]FDG accumulation to tori tubarius was performed along with the clinical features and histopathological analysis. Results Of the 48 patients, abnormal [ 18 F]FDG accumulation (metabolic tumour volume ≥ 1) to tori tubarius was observed in 15 (31.3%), all of whom had lesions in other head and neck glands. IgG4-RD patients with abnormal [ 18 F]FDG accumulation to tori tubarius showed swollen nasopharyngeal walls around tori tubarius and forceps biopsy of the lesion revealed acinar cells and IgG4-positive plasma cells histologically. Abnormal [ 18 F]FDG accumulation (maximum standard uptake value, metabolic tumour volume and total lesion glycolysis) to tori tubarius correlated with higher IgG4 and lower IgA serum concentrations. Conclusions Abnormal [ 18 F]FDG accumulation to tori tubarius can be observed in patients with IgG4-RD and the abnormal [ 18 F]FDG accumulation to tori tubarius can be a clue of TG involvement in IgG4-RD.
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Key words
Positron emission tomography with [ 18 F]fluorodeoxyglucose
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