Editorial: Engineered extracellular vesicles for tissue repairing

As a cell-free therapy, engineered extracellular vesicles have higher safety, lower immunogenicity 76 and higher targeting, compared with stem cell therapy. In addition to the clinical applications 77 mentioned above, EVs have also found application value in cardiac repair, fatty liver treatment and 3 other fields (Wang et al.,2021;Pezzana et al.,2021). How to obtain therapeutic EVs with a well 79 targeting property and good efficacy is the biggest challenge to promote its clinical application. EVs' 80 excellent ability in cell-growth promoting, anti-inflammatory and immune regulatory effects will 81 widen its application in an increasing number of clinical fields. 82