Organochlorine pesticides and epigenetic alterations in thyroid tumors.

Fouzieh Salimi,Gholamreza Asadikaram, Mohammad Reza Ashrafi,Hamid Zeynali Nejad,Moslem Abolhassani,Mojtaba Abbasi-Jorjandi,Mojgan Sanjari

Frontiers in endocrinology（2023）

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摘要

The current research indicated that OCPs could contribute to PTC progression by TSHR promoter hypermethylation and decreased acetylation of H3K9 and H4K16. In addition, in PTC patients, assessing TSHR promoter methylation and acetylation of H3K9 and H4K16 could have predictive values.

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关键词

thyroid tumors, DNA methylation, histone modification, organochlorine pesticides, epigenetic alterations

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