Overexpression of ZEB1 and YAP1 is related to poor prognosis in patients with gliomas with different IDH1 status.

Na Miao, Zhi-Qiang Wang,Ning Zhang,Zhi-Ping Ma,Li-Ping Su,Yang-Yang Zhai,Yan-Ran Hu,Wei Sang, Wei Zhang

International journal of clinical and experimental pathology（2023）

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摘要

Our study showed that ZEB1 and YAP1 were significantly activated in GBM, and patients with high ZEB1 and YAP1 expression had worse OS. ZEB1 expression was significantly correlated with YAP1 in glioma. ZEB1 and YAP1 coexpression may serve as a useful prognostic biomarker for glioma, and aberrant YAP1 expression may be associated with IDH1 gene state.

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关键词

gliomas,different idh1 status,zeb1,yap1,prognosis

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