Puerarin alleviated oxidative stress and ferroptosis during renal fibrosis induced by ischemia/reperfusion injury via TLR4/Nox4 pathway in rats.

Jun Jian,Dan Wang,Yufeng Xiong,Jingsong Wang,Qingyuan Zheng,Zhengyu Jiang,Jiacheng Zhong, Song Yang,Lei Wang

Acta cirurgica brasileira（2023）

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摘要

Our results suggested that puerarin inhibited oxidative stress and ferroptosis induced by I/R and, thus, delayed the progression of renal fibrosis, providing a new target for the treatment of renal fibrosis.

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关键词

oxidative stress,renal fibrosis,ferroptosis,ischemia/reperfusion injury,puerarin

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