Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma.

Timothy E Richardson,Raquel T Yokoda,Omid Rashidipour,Meenakshi Vij,Matija Snuderl,Steven Brem,Kimmo J Hatanpaa,Samuel K McBrayer,Kalil G Abdullah,Melissa Umphlett,Jamie M Walker,Nadejda M Tsankova

Neuro-oncology advances（2023）

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摘要

These results suggest that whether present initially or in response to therapy, MMR mutations significantly affect TMB but appear to only influence the clinical outcome in IDH-mutant astrocytoma subsets.

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关键词

glioblastoma,protein mutations,isocitrate dehydrogenase,idh-wild-type

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