Targeting hypoxia-induced CBS expression inhibits breast cancer stem cells through the induction of ferroptosis.

Guangyao Wei,Jia Liu,Jie Lan,Guangyu Ji, Huize Xia, Zhiqun Zhao, Zhaoxue Yu,Rong Sun,Chuanzhao Zhang,Haiquan Lu

Genes & diseases（2023）

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摘要

Triple-negative breast cancer(TNBC)has a poor prognosis because of its aggressive characteristics and lack of tar-geted therapies.1 Recently,it has been reported that TNBC is sensitive to ferroptosis,an iron-dependent type of pro-grammed cell death,making it a potential target for the treatment of TNBC.2

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