Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis.

Johanna Melin,Maria Forslund,Simon Alesi,Terhi Piltonen,Daniela Romualdi,Poli Mara Spritzer,Chau Thien Tay,Alexia Pena,Selma Feldman Witchel,Aya Mousa,Helena Teede

The Journal of clinical endocrinology and metabolism（2023）

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摘要

The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.

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