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Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis.

Shihao Xie,Jiaxin Li, Fengyuan Lyu,Qingming Xiong,Peng Gu,Yuqi Chen,Meiling Chen,Jingna Bao,Xianglong Zhang,Rongjuan Wei, Youpeng Deng, Hongzheng Wang,Zhenhua Zeng,Zhongqing Chen,Yongqiang Deng,Zhuoshi Lian,Jie Zhao,Wei Gong,Ye Chen,Ke-Xuan Liu,Yi Duan,Yong Jiang,Hong-Wei Zhou,Peng Chen

Gut（2023）

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Abstract
We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice.
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Key words
sepsis, probiotics, macrophages, inflammation, intestinal microbiology
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