A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination br

Aortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. Wepresent a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with de-velopment of infective endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a youngfemale patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valvelesions, as it made it possible to identify the true cause of the disease. The presence of Takayasu arteritis has played an indirect role by creatingconditions for the development of immunosuppression and determining the disease severity and its progression.