Treatment activity of hydrogels loaded with copper metal-organic frameworks of dacarbazine on melanoma by modulating melanoma prognostic markers S₁₀₀A₆ and VEGFa

In the present paper, a new Cu(II)-based coordination polymer (CP) with the chemical composition of [Cu-2(mu(4)-btca)(phen)(2)(H2O)(2)](n) n (1) was synthesized and successfully loaded with the drug dacarbazine. Based on the chemical synthesis method, HA/CMCS hydrogels loaded with copper metal-organic frameworks of dacarbazine were prepared. SEM results showed the hydrogels had a typical macroporous structure with good penetration between the pores. The results of the CCK-8 assay showed the hydrogels could substantially reduce the viability of the melanoma cells. In addition, the hydrogels reduced the migration and invasive ability of cancer cells in a dose-dependent manner by suppressing the expression of melanoma prognostic markers VEGFa and S(100)A(6), which is a promising application for the treatment of melanoma.