Myeloid dendritic cells are increased in the lesional skin and associated with pruritus in patients with prurigo nodularis.
MedComm(2023)
Abstract
The number of dermal mDCs (CD11c cells) was increased with itch intensity ( = 0.886, = 0.003) using immunofluorescence (IF). On IF, CD11c mDCs expressed IL-31 in lesional PN skin. Fluorescence in situ hybridization combined with IF also confirmed IL-31 mRNA expression by mDCs in PN lesion. Higher population of colocalization of CD11c mDCs expressing IL-31 mRNA were more than CD68 macrophages and CD3 T cells in consecutive sections of PN skin lesion. HC, healthy control; PN, prurigo nodularis; SPN, PN with severe pruritus (itch NRS score ≥7 points); MPN, PN with mild pruritus (itch NRS score <3 points); NRS, Numeric Rating Scale; AD, atopic dermatitis; mDC, myeloid dendritic cell.
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Key words
prurigo nodularis,dendritic cells,pruritus,lesional skin
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