Investigation of DKK-1 (DICKKOPF-1) and DKK-3 (DICKKOPF-3) levels before and after cardiopulmonary bypass

Aim: According to recent studies related to coronary artery diseases, Dkk-1(Dickkopf-1) and Dkk-3(Dickkopf-3) levels in the blood have been found to be associated with the onset and progression of atherosclerosis. This study was carried out to investigate Dkk-1 and Dkk-3 levels in patients who underwent surgery with the cardiopulmonary bypass method.Material and Methods: Thirty patients who were operated on by the cardiopulmonary bypass method were included in this study. Venous blood samples were taken from the patients before and after cardiopulmonary bypass, and Dkk-1 and Dkk-3 proteins were measured using the ELISA method.Results: As a result of the study, a statistically significant difference was observed between Dkk-1 values measured before and after cardiopulmonary bypass (p<0.01). Likewise, there was a statistically significant difference between Dkk-3 values measured before and after cardiopulmonary bypass (p<0.05).Discussion: The decrease in Dkk-1 and Dkk-3 levels before cardiopulmonary bypass after surgery shows that these values are important in terms of protection against atherosclerosis. With these parameters, which have been observed to have protective effects against the formation of atherosclerosis and against atherosclerosis, possible heart damage can be prevented with therapeutic strategies that reduce myocardial damage.