Copper-Catalyzed Coupling of N -Phenoxyacetamides and 2H -Azirines for Synthesis of a-Amino Oxime Ethers
SYNTHESIS-STUTTGART(2023)
摘要
Copper-catalyzed coupling reaction involving N-phenoxy-acetamides and 2H-azirines is described, in which N-O and C-N bonds are broken and restructured. This protocol provides an efficient strategy for the highly regioselective synthesis of racemic ?-amino oxime ethers. In addition, this strategy can be used to modify natural products and is gram-scale compatible.
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关键词
copper catalysis, N -phenoxyacetamides, 2H-azirines, ring-opening reactions, & alpha,-amino oxime ethers
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