Validated and selective potentiometric analysis of anti-coagulant edoxaban via a screen-printed electrode: green assessment by Eco-Scale and Complex-GAPI

Thromboembolism because of coronavirus infection (COVID-19) resulted in increasing the number of sudden deaths after recovery. So, patients were switched to edoxaban tosylate monohydrate (EDTM) therapy after low molecular weight heparin to shorten the hospitalization period. In response to increase the demand for EDTM, we developed a home-made screen-printed electrode to determine EDTM in its pure form and pharmaceutical dosage form. Optimized conditions were achieved with a screen-printed electrode utilizing EDTM-Phosphotungstic acid (EDTM-PTA) as an ion pair complex and a plasticizer dibutyl phthalate with a Nernstian slope of 58.78 ± 0.1 mV decade −1 at the concentrations ranging from 5.0 × 10 –6 to 1.0 × 10 –2 M EDTM ( R 2 = 0.9985). The detection limit was 4.3 × 10 –6 M. Our method was proven to be eco-friendly after assessment by Eco-Scale and Complex-GAPI. The results obtained were validated according to ICH guidelines and were found to agree with those gained from the reference method.