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Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination.

Ana Beatriz Ayroza Galvão Ribeiro Gomes,Laila Kulsvehagen,Patrick Lipps,Alessandro Cagol,Nuria Cerdá-Fuertes,Tradite Neziraj,Julia Flammer, Jasmine Lerner,Anne-Catherine Lecourt,Nina de Oliveira S Siebenborn,Rosa Cortese,Sabine Schaedelin,Vinicius Andreoli Schoeps,Aline de Moura Brasil Matos,Natalia Trombini Mendes,Clarissa Dos Reis Pereira,Mario Luiz Ribeiro Monteiro,Samira Luisa Dos Apóstolos-Pereira,Patrick Schindler,Claudia Chien,Carolin Schwake,Ruth Schneider,Thivya Pakeerathan,Orhan Aktas,Urs Fischer,Matthias Mehling,Tobias Derfuss,Ludwig Kappos,Ilya Ayzenberg,Marius Ringelstein,Friedemann Paul,Dagoberto Callegaro,Jens Kuhle,Athina Papadopoulou,Cristina Granziera,Anne-Katrin Pröbstel

JAMA neurology（2023）

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Abstract
In this study, MOG-specific IgA was identified in a subgroup of patients who were double-seronegative for AQP4-/MOG-IgG, suggesting that MOG-IgA may be a novel diagnostic biomarker for patients with CNS demyelination.
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Key words
myelin oligodendrocyte glycoprotein,antibodies,central nervous system
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