Phenylacetylglutamine and trimethylamine N-oxide: Two uremic players, different actions.
European journal of clinical investigation(2023)
摘要
In conclusion, our translational data confirm TMAO's pro-calcifying effects, but both toxins induced free radical production detrimental to vascular maintenance. Our findings suggest these gut-derived uremic toxins have different actions on the vessel wall and therapeutically targeting TMAO may help reduce CV-related mortality in CKD.
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关键词
kidney failure, oxidative stress, phenylacetylglutamine, TMAO, vascular calcification
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