Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture.
bioRxiv : the preprint server for biology(2023)
摘要
We identified hCO phenotypes that are reproducible across sites using a harmonized differentiation protocol. Previously described limitations of hCO models were also reproduced including off-target differentiations, necrotic cores, and cellular stress. Improving our understanding of how stem cell states influence early hCO cell types may increase reliability of hCO differentiations. Cross-site reproducibility of hCO cell type proportions and organization lays the foundation for future collaborative prospective meta-analytic studies modeling neurodevelopmental disorders in hCOs.
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关键词
human cortical organoids,consistent cell type composition,cross-site
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