Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells.

Kevin MingJie Gao,Kerstin Nündel,Kristy Chiang, Xihui Yin,Paul J Utz,Kate Fitzgerald,Ann Marshak-Rothstein

bioRxiv : the preprint server for biology（2023）

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摘要

Chimeric mice expressing STING only in non-hematopoietic cells develop systemic and lung directed autoimmunity which recapitulates what is seen in pediatric patients with SAVI disease.

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关键词

autoreactive lymphocytes,lung,cells,gain-of-function

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