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Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis.

Lonneke A van Tuijl,Maartje Basten,Kuan-Yu Pan,Roel Vermeulen,Lützen Portengen,Alexander de Graeff,Joost Dekker,Mirjam I Geerlings,Adriaan Hoogendoorn,Femke Lamers,Adri C Voogd,Jessica Abell,Philip Awadalla,Aartjan T F Beekman,Ottar Bjerkeset,Andy Boyd,Yunsong Cui,Philipp Frank,Henrike Galenkamp,Bert Garssen,Sean Hellingman,Martijn Huisman,Anke Huss,Trynke R de Jong,Melanie R Keats,Almar A L Kok,Steinar Krokstad,Flora E van Leeuwen,Annemarie I Luik,Nolwenn Noisel,N Charlotte Onland-Moret,Yves Payette,Brenda W J H Penninx,Ina Rissanen,Annelieke M Roest,Rikje Ruiter,Robert A Schoevers,David Soave,Mandy Spaan,Andrew Steptoe,Karien Stronks,Erik R Sund,Ellen Sweeney,Emma L Twait,Alison Teyhan,W M Monique Verschuren,Kimberly D van der Willik,Judith G M Rosmalen,Adelita V Ranchor

Cancer（2023）

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Abstract
Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. PREREGISTRATION NUMBER: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.
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Key words
anxiety, cancer, depression, meta-analysis, risk
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