Ursolic Acid Derivatives Bearing 1,2,3-triazole Moieties as Potential PTP1B Inhibitors

Chemistry of Natural Compounds(2023)

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摘要
Here, a series of ursolic acid (UA) derivatives were identified as potential PTP1B enzyme inhibitors. All of the tested compounds showed potent PTP1B inhibitory activity (87.79–96.80%) at a concentration of 20 μg/mL and dose-dependently inhibited PTP1B enzyme with IC 50 values ranging from 4.15 ± 0.01 to 14.10 ± 0.45 μM. Compound 11e showed the best PTP1B inhibitory potency, with IC 50 values of 4.15 ± 0.01 μM, which was slightly lower than that of the positive control. Molecular docking simulation and analysis suggested that compound 11e has a good binding interaction with the active pocket.
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关键词
ursolic acid,PTP1B inhibitors,dose-dependently,molecular docking
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