High-Capacity Calcium Carbonate Particles As pH-Sensitive Containers for Doxorubicin

Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO3:Si:Fe nanoparticles 65 ± 15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent, as well as its release under model conditions at different рН, is determined.