Positive effects of Pycnogenol®-Centellicum® on venous elasticity: an ex-vivo concept study.

In this study, Pycnogenol-Centellicum improved vein elasticity in subjects with normal and varicose veins as vein segments were more elastic (able to recover length and shape) and less passively dilated by high pressure or dynamic stresses. This study indicates that the protective effects of Pycnogenol-Centellicum may partially stop passive dilatation of veins to varicose veins over time by improving vein elasticity. Pycnogenol-Centellicum managed vein segments return more rapidly back to the initial dimensions, shapes and diameters after a dynamic stress.