Acute exacerbation of idiopathic pulmonary fibrosis model in the rats using bleomycin and lipopolysaccharides.

Sandy Vitria Kurniawan,Melva Louisa,Jamal Zaini, Silvia Surini,Vivian Soetikno,Puspita Eka Wuyung,Rosemary Ceria Tatap Uli

Journal of advanced veterinary and animal research（2023）

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摘要

By combining BLM and LPS, it was possible to create a successful rat model of AE-IPF. The present model showed the peak exacerbation on Day 8 and the fibrotic peak on Day 14, which gradually improved. The optimal time for the new AE-IPF therapeutic intervention was determined to be between Days 8 and 14.

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关键词

idiopathic pulmonary fibrosis model,pulmonary fibrosis,bleomycin

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