Synergistic efficacy of PI3Kδ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer.

Yingjue Li,Yiwen Li,Yu Yang,Yuwei Deng, Xiangdong Ni,Bochen Zhao,Zhaoqi Yan, Wen He, Yixin Li,Shuhui Li,Linbo Liu,Dan Lu

Heliyon（2023）

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摘要

Our study suggests PI3Kδ inhibitor could the enhance the efficacy of ICIs in HR + BC PDX models by combating immune suppression and provides a feasible approach that may overcome the resistance of ICIs in HR + BC patients.

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关键词

Breast cancer (BC), Patient-derived xenograft, Immune checkpoint inhibitors, Endocrine therapy resistance, Humanized mice

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